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Comparative Metabolic
Longevity Cell Atlas (CMLCA)
Decoding the cellular biology of long lifespan
through multispecies stem cell science
What is CMLCA?
The Comparative Metabolic Longevity Cell Atlas (CMLCA) is a cross-species stem cell platform to decode how evolution over millions of years shapes cellular resilience to aging through metabolic adaptations.
By analyzing matched iPSC derived cells from short- and long-lived mammals - from mouse to elephant - we're uncovering deeply conserved, organelle-level metabolic mechanisms that regulate lifespan.
Our current cell panel spans mammalian species over 90 million of years of evolutionary distance, including rodent, primate, ungulate and megafauna lineages - each offering distinct insights into metabolic longevity
CMLCA is designed as an independent, globally collaborative initiative with a flexible infrastructure, enabling partnership across institutions, geographies and scientific domains.
Evolutionary
Scope
Over 90 millions of years of mammalian divergence represented through unique iPSC and matched cell resources
Organelle
Profiling
Mitochondria, lysosomes, peroxisomes and proteasomes analyzed for metabolic and proteostatic function
Functional
Assays
Stress resilience, metabolic homeostasis, proteostasis across matched somatic cell types
Open
Science
Processed data and comparative insights shared via publications and a publicly available Longevity Metabolic Atlas
We believe evolution holds the blueprint for biological resilience. CMLCA reveals the cellular architecture of long life - and shares it with the world
Collaborators and Contributors:
We are grateful for the insight, encouragement, and emerging collaboration with the colleagues of the following institutions
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Medical University of Vienna, Austria
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SBRI (Inserm), France
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German Primate Center, Germany
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Leibniz Institute for Zoo and Wildlife Research, Germany
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iThemba LABS NR, South Africa
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IOCB, Czech Republic
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NUS, Singapore
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UBC, Canada